The research is interested in shedding light on the historical framework of US-Iranian relations since 1979, and the political events that have permeated it, which later reflected the imposition of a number of US sanctions on Iran, which directly affected the formulation of its foreign policy towards Arab and international countries. The problem of research revolves around the recent US sanctions against Iran in 2018, and as many historians and economists put it, "it is the most severe" as it includes oil exports, shipping, and banks, while targeting any company or organization that circumvents the implementation of the sanctions. As far as the matter is concerned with Iraq, the research is interested in stating the extent of its influence on the sanctions imposed on Iran, in economic terms, the volume of trade exchange, and the Iraqi market. The research was divided into an introduction and three axes, the first concerned with giving the historical framework for US-Iranian relations after 1979. The second topic focused on highlighting the sanctions imposed on Iran since 1979. As for the last topic, it indicated the repercussions of the sanctions on the Iraqi economy.